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Oncology Course

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Regulation and Functional analysis of
tumor suppressor genes
Dr. Kumaravel Somasundaram
Associate professor
Microbiology and cell Biology
Indian Institute of Science, Bangalore-560 012.
Karnataka, India.
Phone:+91 80
23607171 (Office)
          
 +91 80 22932973 (Lab)
Fax    :+91 80 23602697
Email :
skumar@mcbl.iisc.ernet.in

Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. Transformation is the process by which a normal cell becomes a cancer cell.  The two main classes of genes that are now recognized as playing a role in cancer are oncogenes and tumor suppressor genes.  Oncogenes are mutated forms of genes that cause normal cells to grow out of control and become cancer cells.  Tumor suppressor genes are normal genes that slow down cell division, repair DNA mistakes, and induce programmed cell death.  When tumor suppressor genes don't work properly, cells can grow out of control, which can lead to cancer.  Kumarís lab is studying the molecular mechanisms behind cell transformation, with special focus on regulation and functional analysis of tumor suppressor gene families: p53, BRCA1/2 and AP-2.


 
          
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